Characterization of Lung Function Parameters and Associated Factors In Children In Havana

Authors

Keywords:

lung function, preschoolers.

Abstract

Introduction: Knowledge of lung function parameters in the outpatient population and associated factors is scarce in Cuba. Objective: To describe selected lung function parameters and to identify associated factors in children in Havana. Methods: A cross-sectional study was conducted in 903 children in Havana, 5 to 6 years old, from 2015 to 2016. ISAAC questionnaire was applied, including sociodemographic factors, prenatal, perinatal, environmental, lifestyle and anthropometric measurements. Forced spirometry was performed with a salbutamol reversibility test and FEV1, FVC and FEV1/FVC were recorded. Simple and multivariate linear regression, percentages, means and standard deviation with their confidence intervals were used (significant regression if p < 0.05). Results: FEV1 (77%), FVC (67.3%) and FEV1/FVC (59.3%) increased, with a higher rate in boys. The main associated factors were: prenatal history of anemia, maternal age < 20 or > 35 years, underweight or overweight, family history of asthma, helminthiasis, dengue and pneumonia, exposure to environmental tobacco smoke and air pollution. Conclusions: The differential parameters of children lung function in Havana do not differ from those in the rest of the world. Modifiable prenatal, nutritional and environmental factors are involved in lung function. Further studies are needed to further investigate the new associations identified.

Downloads

Download data is not yet available.

References

1. Agustí A, Noell G, Brugada J, Faner R. Lung function in early adulthood and health in later life: a transgenerational cohort analysis. Lancet Respir Med. 2017;5(12):935-45. DOI: https://doi.org/10.1016/S2213-2600(17)30434-4

2. Talaminos Barroso A, Márquez Martín E, Roa Romero LM, Ortega Ruiz F. Factores que afectan a la función pulmonar: una revisión bibliográfica. Arch Bronconeumol. 2018;54(6):327-32. DOI: https://doi.org/10.1016/j.arbres.2018.01.030

3. Bui DS, Lodge CJ, Burgess JA, Lowe AJ, Perret J, Bui MQ, et al. Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life. The Lancet. 2018;6(7):535-44. DOI: https://doi.org/10.1016/S2213-2600(18)30100-0

4. Jiménez-García R, García-Sánchez J, Rojo-Concepción M, Salup-Díaz R, Lavandero-Morales N. ¿Puede la intervención nutricional modificar la función pulmonar en el niño con Fibrosis Quística? Rev Cubana Alim Nutr. 2010 [acceso 04/10/2023];20(2). Disponible en: https://revalnutricion.sld.cu/index.php/rcan/article/view/741

5. Reyes Hernández D, García Canales M, Simón Ortega P, Pérez García K. Repercusión del hábito de fumar en la función pulmonar de fumadores activos. Rev Cub Med Mil. 2011 [acceso 04/10/2023];40(3-4):227-33. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572011000300004&lng=es

6. Mazorra-Zamora R, Palenzuela F, Morenza V. La función pulmonar en los deportistas. Rev Cubana Med. 2019 [acceso 04/10/2023];6(3). Disponible en: https://revmedicina.sld.cu/index.php/med/article/view/763

7. Venero-Fernandez S, Suarez-Medina R, Mora-Faife E, Garcia-Garcia G, Valle-Infante I, Gomez-Marrero L, et al. Risk factors for wheeze in infants in Cuba. Risk Quarterly J Med. 2013;106:1023-29. DOI: https://doi.org/10.1186/1471-5945-14-6

8. Suarez-Medina R, Venero-Fernández SJ, Mora-Faife EC, García-García G, Valle-Infante I, Gómez-Marrero L, et al. Risk factors for eczema in infants born in Cuba. BMC Dermatol. 2014;14:6. DOI: http://doi.org/10.1186/1471-5945-14-6

9. Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, et al. General considerations for lung function testing. Eur Respir J. 2005;26:153-61. DOI: https://doi.org/10.1183/09031936.05.00034505

10. Venero-Fernández SJ. Sibilancia en la infancia precoz. La Habana 2008-2013 [tesis]. La Habana: Universidad de Ciencias Médicas de La Habana; 2017 [acceso 04/10/2023] Disponible en: http://tesis.sld.cu/index.php?P=FullRecord&ID=650ENSALUD

11. Centro de Estudios de Población y Desarrollo. Anuario demográfico de Cuba 2017. La Habana: Oficina Nacional de Estadística e Información; 2018 [acceso 04/10/2023]. Disponible en: https://onei.gob.cu

12. Veras TN, Pinto LA. Feasibility of spirometry in preschool children. J Bras Pneumol. 2011;37(1):69-74. DOI: https://doi.org/10.1590/S1806-37132011000100011

13. Burrill A, McArdle C, Davies B. Lung function in children: a simple guide to performing and interpreting spirometry. Paediatrics and Child Health. 2021;31(7):276-83. DOI: https://doi.org/10.1016/j.paed.2021.04.003

14. Vasquez MM, Zhou M, Hu C, Martinez FD, Guerra S. Low Lung Function in Young Adult Life Is Associated with Early Mortality. Am J Respir Crit Care Med. 2017;195(10):1399-401. DOI: https://doi.org/10.1164/rccm.201608-1561LE

15. Akhiwu HO, Aliyu I. Spirometric Values in healthy Nigerian school children aged 6-11 years. Journal of Advances in Medicine and Medical Research. 2017;22(9):1-8. DOI: https://doi.org/10.9734/JAMMR/2017/34804

16. Belgrave DCM, Buchan I, Bishop C, Lowe L, Simpson A, Custovic A. Trajectories of Lung Function during Childhood. Am J Respir Crit Care Med. 2014;189(9):1101-9. DOI: https://doi.org/10.1164/rccm.201309-1700OC

17. Trisán Alonso A. Prueba broncodilatadora. Rev Asma. 2016 [acceso 04/11/2023];1(2):60-67. Disponible en: https://separcontenidos.es/revista3/index.php/revista/article/view/101/113

18. LoMauro A, Aliverti A. Sex differences in respiratory function. Breathe. 2018;14(2):131-40. DOI: https://doi.org/10.1183/20734735.000318

19. Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: The global lung function 2012 equations. Eur Respir J. 2012;40(6):1324-43. DOI: https://doi.org/10.1183/09031936.00080312

20. Armengaud J, Yzydorczyk C, Siddeek B, Peyter A, Simeoni U. Intrauterine growth restriction: clinical consequences on health and disease at adulthood. Reproductive Toxicology. 2021;99:168-76. DOI: https://doi.org/10.1016/j.reprotox.2020.10.005

21. Doyle LW, Andersson S, Bush A, Cheong JLY, Clemm H, Evensen K, et al. Expiratory airflow in late adolescence and early adulthood in individuals born very preterm or with very low birthweight compared with controls born at term or with normal birthweight: a meta-analysis of individual participant data. Lancet Respir Med. 2019;7:677-86. DOI: https://doi.org/10.1016/s2213-2600(18)30530

22. Bårdsen T, Røksund OD, Benestad MR, Hufthammer KO, Clemm HH, Mikalsen IB, et al. Tracking of lung function from 10 to 35 years after being born extremely preterm or with extremely low birth weight. Thorax. 2022;77(8):790-8. DOI: https://doi.org/10.1136/thoraxjnl-2021-218400

23. Jiménez Acosta SM, Rodríguez Suárez A, Pita Rodríguez G. Prevalencia de anemia durante el embarazo en Cuba. Evolución en 15 años. Rev Esp Nutr Comunitaria. 2014;20(2):42-7. DOI: https://doi.org/10.7400/RENC.2014.01.2.5009

24. Karaçam Z, Kizilca Çakaloz D, Demir R. The impact of adolescent pregnancy on maternal and infant health in Turkey: Systematic review and meta-analysis. J Gynecol Obstet Hum Reprod. 2021;50(4). DOI: https://doi.org/10.1016/j.jogoh.2021.102093

25. Marcheco-Teruel B, Fuentes Smith E, Marín Padrón LC, Gómez Cabezas EJ. Cuba: Estudio de la historia del mestizaje y de las bases genéticas de la pigmentación de la piel utilizando marcadores autosómicos y uniparentales. Anales de la Academia de Ciencias de Cuba. 2016 [acceso 31/03/2024]. Disponible en: https://revistaccuba.sld.cu/index.php/revacc/article/view/298

26. Albizu-Campos Espiñeira JC, Cabrera Marrero F. La mortalidad en Cuba según el color de la piel. Rev Novedades en Población. 2014 [acceso 31/03/2024];10(20):31-61. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1817-40782014000200004&lng=es&tlng=es

27. Alfonso León AC. Los cubanos y el cuidado de la salud. Un enfoque según el color de la piel. Universidad de La Habana. 2023 [acceso 04/10/2023];273. Disponible en: https://revistas.uh.cu/revuh/article/view/3194

28. Braun L. Race, ethnicity and lung function: A brief history. Can J Respir Ther. 2015 [acceso 04/10/2023];51(4):99-101. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631137/pdf/cjrt-51-99.pdf

29. Brehm JM, Acosta-Pérez E, Klei L, Roeder K, Barmada MM, Boutaoui N, et al. African ancestry and lung function in Puerto Rican children. J Allergy Clin Immunol. 2012;129(6):1484-90. DOI: https://doi.org/10.1016/j.jaci.2012.03.035

30. Harik Khan RI. Fleg JL, Muller DC, Wisethe RA. Effect of anthropometric and socioeconomic factors on the racial difference in lung function. Am J Respir Crit Care Med. 2001;164:1647-54. DOI: https://doi.org/10.1164/rccm2106075

31. Schultz ES, Hallberg J, Andersson N, Thacher JD, Pershagen G, Bellander T, et al. Early life determinants of lung function change from childhood to adolescence. Respiratory Medicine. 2018;139:48-54. DOI: https://doi.org/10.1016/j.rmed.2018.04.009

32. Gauderman WJ, Urman R, Avol E, Berhane K, McConnell R, Rappaport E, et al. Association of improved air quality with lung development in children. New England J Med. 2015;372(10):905-13. DOI: https://doi.org/10.1056/NEJMoa1414123

33. Agier L, Basagaña X, Maitre L, Granum B, Bird PK, Casas M, et al. Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort. The Lancet Planetary Health. 2019;3(2). DOI: https://doi.org/10.1016/S2542-5196(19)30010-5

34. Cai Y, Hansell AL, Granell R, Blangiardo M, Zottoli M, Fecht D, et al. Prenatal, Early-life and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort. Am J Resp Critical Care Med. 2020;202(1):112-23. DOI: https://doi.org/10.1164/rccm.201902-0286oc

35. Garcia E, Rice MB, Gold DR. Air pollution and lung function in children. J Allergy Clin Immunol. 2021;148(1):1-14. DOI: https://doi.org/10.1016/j.jaci.2021.05.006

36. Gibbs K, Collaco JM, McGrath-Morrow SA. Impact of tobacco smoke and nicotine exposure on lung development. Chest. 2016;149(2):552-61. DOI: https://doi.org/10.1378/chest.15-1858

37. Souza Rodrigues R, Garcia Brum AL, Paes MV, Póvoa TF, Basilio-de-Oliveira CA, Marchiori E, et al. Lung in Dengue: Computed Tomography Findings. PLoS One. 2014;9(5). DOI: https://doi.org/10.1371/journal.pone.0096313

38. Whittaker S, Bell M, Deziel N, Zhang. Air Pollution and Infectious Disease Burdens on Lung Function in the Eastern Caribbean. International Society for Environmental Epidemiology (ISEE) Annual Meeting. Ottawa, Canada. 2018. DOI: https://doi.org/10.1289/isesisee.2018.O04.01.14

Published

2025-03-18

How to Cite

1.
Suárez-Medina R, Venero-Fernández SJ, Fogarty AW. Characterization of Lung Function Parameters and Associated Factors In Children In Havana. Rev Cubana Pediatría [Internet]. 2025 Mar. 18 [cited 2025 Jul. 1];97. Available from: https://revpediatria.sld.cu/index.php/ped/article/view/7303