Factors associated with BCG vaccination coverage in infants according to a demographic survey in Peru
Keywords:
Cobertura de inmunización, vacuna BCG, infantes, encuesta demográfica, Perú, TuberculosisAbstract
Introduction: The BCG vaccine is crucial against tuberculosis, but it faces coverage challenges in Peru that affect the implementation and access.
Objective: To determine the factors associated with BCG vaccination coverage in infants under six years of age, according to the 2022 Demographic and Family Health Survey.
Methods: This is an observational, descriptive, cross-sectional, analytical, and retrospective study using secondary data from the 2022 Demographic Survey. The sample consisted of children under six years of age, children of women between 12 and 49 years of age, excluding incomplete surveys. Variables included sociodemographic information and characteristics of each child, their parents, and the household. The statistical analysis was performed using univariate, bivariate, and multivariate methods using SPSS 26 and Excel 2019.
Results: Among 11,598 eligible children, BCG vaccination coverage was 94.3%. Coverage was significantly higher among children whose mothers had completed secondary education (PR = 1.073; 95% CI: 1.033-1.115), those who had received growth and development checks (PR = 1.018; 95% CI: 1.008-1.028), and those in the second wealth quintile compared to the lowest (PR = 1.035; 95% CI: 1.022-1.048). Conversely, coverage was significantly lower among children in rural areas compared to urban areas (PR = 0.971; 95% CI: 0.961-0.981) and among those from the natural jungle region compared to those from Metropolitan Lima (PR = 0.988; 95% CI: 0.983-0.994).
Conclusions: Social disparities in BCG vaccination coverage must be addressed to ensure equitable protection against tuberculosis in the Peruvian child population.
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References
1. Dionato FAV, Jalalizadeh M, Buosi K, Visacri MB, Dal-Col LSB, Giacomelli CF, et al. BCG vaccine safety in COVID-19 convalescent adults: BATTLE a randomized controlled trial. Vaccine. 2022;40(32):4603-8. DOI: https://doi.org/10.1016/j.vaccine.2022.06.039
2. Zhelezova G, Mateeva V, Mateev G. Is the BCG vaccine a useful tool against COVID-19? Clin Dermatol. 2021;39(1):98-103. DOI: https://doi.org/10.1016/j.clindermatol.2020.12.018
3 Singh AK, Netea MG, Bishai WR. BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases. The Journal of clinical investigation. 2021:131(11). DOI: https://doi.org/10.1172/JCI148291
4. Goudouris E, Aranda CS, Solé D. Implications of the non-specific effect induced by Bacillus Calmette-Guerin (BCG) vaccine on vaccine recommendations. Jornal de pediatria. 2023;99(Suppl1):S22-S7. DOI: https://doi.org/10.1016/j.jped.2022.09.002
5. Kuan R, Muskat K, Peters B, Lindestam Arlehamn CS. Is mapping the BCG vaccine-induced immune responses the key to improving the efficacy against tuberculosis? J Intern Med. 2020;288(6):651-60. DOI: https://doi.org/10.1111/joim.13191
6. WHO [homepage en Internet]. Bacille Calmette-Guérin (BCG) vaccination. Geneva: World Health Organization; 2015 [acceso 04/04/2024]. Disponible en: https://www.who.int/publications/i/item/WHO-HTM-TB-2015.19
7. Asociación Española de Pediatría [homepage en Internet]. España: coberturas de vacunación 2022 en el mundo: recuperación, pero escasa y desigual; 2023 [acceso 04/04/2024]. Disponible en: https://vacunasaep.org/profesionales/noticias/cobertura-vacunales-en-el-mundo-2022
8. World Health Organization [homepage en Internet]. Bacille Calmette-Guérin (BCG) vaccination coverage; 2022 [acceso 04/04/2024]. Disponible en: https://www.who.int/news-room/feature-stories/detail/how-do-vaccines-work?adgroupsurvey={adgroupsurvey}&gad_source=
9. Atalell KA, Alemayehu MA, Teshager NW, Belay GM, Alemu TG, Anlay DZ, et al. Mapping BCG vaccination coverage in Ethiopia between 2000 and 2019. BMC Infect Dis. 2022;23(1):569. DOI: https://doi.org/10.1186/s12879-022-07547-4
10. Kantor Isabel N. ¿BCG versus COVID-19? Medicina (B. Aires). 2020 [acceso 08/04/2024];80(3):292-4. Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802020000400015&lng=es
11. Bazán-Ruiz S, Ancajima-More EJ, Lachira AA, Mejia CR. Factores asociados al desarrollo de tuberculosis pulmonar multidrogoresistente en el departamento de Piura, Perú 2009-2014. Infect. 2019;23(1):10-5. DOI: https://doi.org/10.22354/in.v23i1.749
12. Congreso de la República del Perú [homepage en Internet]. Perú: Oficio 145-2023-2024-EJI_CR; 2023 [acceso 07/04/2024]. Disponible en: https://www.congreso.gob.pe/Docs/transparencia-portal/files/2023/1277870-oficio-145-2023-2024-eji_cr-20231005.pdf
13. MINSA [homepage en Internet]. Inmunizaciones; 2023 [acceso 22/04/2024]. Disponible en: https://www.minsa.gob.pe/reunis/data/Inmunizaciones.asp
14. Al-kassab-Córdova A, Silva-Perez C, Maguiña JL. Spatial distribution, determinants and trends of full vaccination coverage in children aged 12–59 months in Peru: A subanalysis of the Peruvian Demographic and Health Survey. BMJ Open. 2022 [acceso 22/04/2024];12(11):e050211. Disponible en: https://bmjopen.bmj.com/content/12/11/e050211
15. Ministerio de Salud [homepage en Internet]. Perú: Boletín Epidemiológico; 2022 [acceso 07/05/2024]. Disponible en: http://bvs.minsa.gob.pe/local/covid/boletin/RM-884-2022-MINSA.pdf
16. INEI [homepage en Internet]. Perú: Encuesta Demográfica y de Salud Familiar 2022 - Nacional y Regional; 2023 [acceso 23/04/2024]. Disponible en: https://www.gob.pe/institucion/inei/informes-publicaciones/4233597-peru-encuesta-demografica-y-de-salud-familiar-endes-2022
17. Fink G, Victoria C, Harttgen K, Vollmer S, et al. Measuring socioeconomic inequalities with predicted absolute income rather than wealth quintiles: A comparative assessment using child stunting data from national surveys. Am J Publi Health. 2017;107:550-5. DOI: https://doi.org/10.2105/AJPH.2017.303657
18. INEI [homepage en Internet]. Resultados de la pobreza monetaria; 2019 [acceso 22/07/2024]. Disponible en: https://www.inei.gob.pe/media/MenuRecursivo/boletines/presentacion-del-jefe-del-inei.pdf
19. Huamán Y. Factores relacionados a sobrepeso y obesidad en niños menores de 5 años en el Perú - según ENDES 2021 [tesis]. Perú: Universidad Ricardo Palma; 2024 [acceso 22/07/2024]. Disponible en: https://hdl.handle.net/20.500.14138/7295
20. Hu Y, Chen Y, Liang H, Wang Y. An Overview of Coverage of BCG Vaccination and Its Determinants Based on Data from the Coverage Survey in Zhejiang Province. Int J Environ Res Public Health; 2018 [acceso 15/05/2024];115(6):1155. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025410/#sec4-ijerph-15-01155title
21. Marbán-Castro E, Sacoor C, Nhacolo A, Augusto O, Jamisse E, López-Varela E, et al. BCG vaccination in southern rural Mozambique: an overview of coverage and its determinants based on data from the demographic and health surveillance system in the district of Manhiça. BMC Pediatr. 2018;18(1):56. DOI: https://doi.org/10.1186/s12887-018-1003-4
22. Mongua-Rodríguez N, Delgado-Sánchez G, Ferreira-Guerrero E, Ferreyra-Reyes L, Martínez-Hernández M, Canizales-Quintero S, et al. Cobertura de vacunación en niños, niñas y adolescentes en México. Salud Publica Mex. 2023 [acceso 02/06/2024];65:s23-s33. Disponible en: https://saludpublica.mx/index.php/spm/article/view/14790
23. Procianoy GS, Cotrim MW, Cia LO, Behar PRP. Impact of BCG vaccination disruptions during the COVID-19 Pandemic on tuberculosis incidence in infants: A nationwide study in Brazil. J Pediatric Infect Dis Soc; 2024;13(3):186-8. DOI: http://dx.doi.org/10.1093/jpids/piae013
24. Ali A, Zar A, Wadood A. Factors associated with incomplete child immunization in Pakistan: findings from Demographic and Health Survey 2017-18. Public Health. 2022 Mar;204:43-48. DOI: https://doi.org/10.1016/j.puhe.2022.01.003
25. Agegnehu CD, Alem AZ. Exploring spatial variation in BCG vaccination among children 0-35 months in Ethiopia: spatial analysis of Ethiopian Demographic and Health Survey 2016. BMJ Open. 2021 Apr 28;11(4):e043565. DOI: https://doi.org/10.1136/bmjopen-2020-043565
26. Sarker AR, Akram R, Ali N, Sultana M. Coverage and factors associated with full immunisation among children aged 12-59 months in Bangladesh: insights from the nationwide cross-sectional demographic and health survey. BMJ Open. 2019 Jul 9;9(7):e028020. DOI: https://doi.org/10.1136/bmjopen-2018-028020
27. Isidro-Ríos Trinidad L, Gutiérrez-Aguado Alfonso. Factores prenatales asociados al incumplimiento del esquema básico de vacunación en menores de 5 años. Rev. Fac. Med. Hum. 2021 [acceso 02/06/2024];21(2):354-63. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2308-05312021000200354&lng=es
28. Hobani F, Alhalal E. Factors related to parents' adherence to childhood immunization. BMC Public Health. 2022;22(1):819. DOI: https://doi.org/10.1186/s12889-022-13232-7
29. Kaway LT, Roldán-Arbieto L, Vela-Ruiz JM, Loo-Valverde M, Guillen Ponce R, Luna-Muñoz C, et al. No cumplimiento del esquema de vacunación nacional en niños menores de 5 años en la selva peruana en el año 2019. Rev. Fac. Med. Hum. 2022 [acceso 04/06/2024];22(4):689-96. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2308-05312022000400689&lng=es
30. Hu Y, Li Q, Chen Y. Timeliness of Childhood Primary Immunization and Risk Factors Related with Delays: Evidence from the 2014 Zhejiang Provincial Vaccination Coverage Survey. Int J Environ Res Public Health. 2017 [acceso 04/06/2024];14(9):1086. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615623/
31. Kefeni BT, Chibsa SE, Roba Debele G. Determinants of incomplete penta vaccination among children aged 12 to 23 months in South-West Ethiopia. Sci Rep. 2024;14(1):1-9. DOI: https://doi.org/10.1038/s41598-024-62153-5
32. Cabada H. Asociación entre vacunación completa y anemia en niños menores de 5 años del Perú, en los años 2019 a 2021. Nutr Clín Diet Hosp; 2023 [acceso 26/04/2024];43(3). Disponible en: https://revista.nutricion.org/index.php/ncdh/article/view/393
33. Mbengue MAS, Mboup A, Ly ID, Faye A, Camara FBN, Thiam M, et al. Vaccination coverage and immunization timeliness among children aged 12-23 months in Senegal: a Kaplan-Meier and Cox regression analysis approach. Pan Afr Med J. 2017 [acceso 05/06/2024];27(Suppl 3):8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745951/
34. Rammohan et al. Paternal education status significantly influences infants’ measles vaccination uptake, independent of maternal education status. BMC Public Health 2012 [acceso 05/06/2024];12:336. Disponible en: https://link.springer.com/article/10.1186/1471-2458-12-336#Sec4
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Copyright (c) 2025 Gianpiere Alexander Palomino Medina, Adely Virginia Nuñez Cardenas, Frank Renato Alvarez Huayán, Arianna Marcela Palomino Motta, Jose Manuel Vela Ruiz, Ricardo Aldo Lama Morales, Maria del Socorro Alatrista Gutiérrez Vda. de Bambarén
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