Assessment of the role of resistin in the metabolic disorders in prepubescent obese children
Keywords:
resistin, children, obesity, micronutrientsAbstract
Introduction: Obesity is one of common causes of the formation of insulin resistance, which triggers a cascade of pathological reactions and the formation of metabolic disorders.
Objective: to evaluate the role of resistin in the metabolic disorders in obese children.
Methods: A cross-sectional, one-stage study was conducted of 38 children at the age of 8-10 years old, 3 groups were identified: 1st – children with obesity (n=16), 2nd –with overweight, 3rd – with normal body weight (n=14). Was assessment of serum levels of resistin, 25(OH)D, parathyroid hormone, calcium, phosphorus, alanine aminotransferase, aspartate aminotransferase, cholesterol, low-density lipoproteins, triglycerides, glucose, insulin, and calculated the index of insulin resistance. The degree of interrelationships was assessed using the Spearman correlation (r). The criterion χ2 was used to determine the relationship between two categorical variables.
Results: The serum resistin concentration increased with increasing Body Mass Index (r=0.9, p<0.05). The median of serum resistin concentration in children with vitamin D deficiency was the highest (p<0.05). In obese children a significant positive correlation was found between the level of resistin and the index of insulin resistance, glucose, cholesterol, triglycerides, and the average number of diagnoses per patient; a strong and moderate negative relationship was established between the level of resistin and serum concentrations of P, Mg, Ca, alkaline phosphatase, and iron.
Conclusions: With increasing serum concentrations of resistin, changes in lipid and carbohydrate metabolism significantly increase, and the content of calcium, phosphorus, alkaline phosphatase, and serum iron decreases, which contributes to the formation of diseases associated with obesity.
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