Clinical Profile and Therapeutic Approach of Neonates with Congenital Gastrointestinal and Abdominal Wall Anomalies

Authors

Keywords:

congenital anomalies; digestive system; newborn; surgery; neonatal intensive care.

Abstract

Introduction: Congenital digestive anomalies constitute an important cause of neonatal morbidity and mortality and frequently require surgical intervention and specialized therapeutic support.

Objective: To characterize the clinical profile and therapeutic management according to the anatomical classification of congenital digestive anomalies in neonates treated at a referral hospital.

Methods: An observational, descriptive, retrospective, cross-sectional study with an analytical component was conducted in 39 neonates with confirmed diagnosis of congenital digestive anomalies, treated between January 2022 and June 2024. Fetomaternal and neonatal variables, anatomical classification of malformations, therapeutic requirements, and hospital outcomes were analyzed. The association between anatomical classification and components of therapeutic management was evaluated, with a significance level of 0.05.

Results: Male neonates predominated (67.0%), born at term (54.0%) and with normal birth weight (64.1%). Abdominal wall malformations accounted for 33.3% of cases and lower digestive tract malformations for 30.8%. Antibiotic therapy was the most used therapeutic component (82.1%), followed by surgical intervention (76.9%) and ventilation (59.0%). A statistically significant association was found between the anatomical classification of malformations and the need for ventilation (p < 0.001), antibiotic therapy (p = 0.001), and surgical intervention (p = 0.001). No deaths were recorded during hospitalization.

Conclusions: The anatomical classification of congenital digestive anomalies is related to differences in therapeutic requirements. Abdominal wall and lower digestive tract malformations present a high need for therapeutic support and surgical intervention.

Downloads

Download data is not yet available.

References

1. Xie X, Pei J, Zhang L, Wu Y. Global birth prevalence of major congenital anomalies: a systematic review and meta-analysis. BMC Public Health. 2025;25(1):449. DOI: https://doi.org/10.1186/s12889-025-21642-6

2. Luo X, Luo J, Zhao J, Du J, Lu D, Gu H. Burden of digestive congenital anomalies among children aged 0-14 years in 204 countries and territories, 1990-2021: results from the Global Burden of Disease Study 2021. BMJ Open. 2024;14(12):e093902. DOI: https://doi.org/10.1136/bmjopen-2024-093902

3. Cai L, Gong H, Geng Q, Lai D, Tou J. Global, regional, and national burden of digestive congenital anomalies from 1990-2021. Pediatr Res. 2025. DOI: https://doi.org/10.1038/s41390-025-04442-x

4. Ab Rahman N, Abdullah MY, Zainal Abidin MA, Nah SA, MYPaedSurg Research Collaboration. Burden and mortality of congenital gastrointestinal anomalies: insights from a nationwide cohort study. Pediatr Surg Int. 2024;40(1):270. DOI: https://doi.org/10.1007/s00383-024-05844-4

5. Lee SM, Lee JA, Chung SH, Lee JH, Shim JW, Lim JW, et al. Nationwide long-term growth and developmental outcomes of infants for congenital anomalies in the digestive system and abdominal wall defects with surgery in Korea. J Korean Med Sci. 2023;38(49):e372. DOI: https://doi.org/10.3346/jkms.2023.38.e372

6. Suryaningrat FR, Wulandari ER, Hudayari D, Ediwan NA, Rakhmilla LE, Kadi FA, et al. Predicting postoperative mortality in neonates with congenital gastrointestinal anomalies: development of a prognostic scoring system. Children (Basel). 2025;12(10):1313. DOI: https://doi.org/10.3390/children12101313

7. Camara S, Fall M, Mbaye PA, Wese SF, Lo FB, Oumar N. Congenital malformations of the gastrointestinal tract in neonates at Aristide Le Dantec University Hospital in Dakar: concerning 126 cases. Afr J Paediatr Surg. 2022;19(3):133-6. DOI: https://doi.org/10.4103/ajps.AJPS_37_21

8. World Medical Association. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA. 2013;310(20):1-95. DOI: https://doi.org/10.1001/jama.2013.281053

9. Jaczyńska R, Mydlak D, Mikulska B, Nimer A, Maciejewski T, Sawicka E. Perinatal outcomes of neonates with complex and simple gastroschisis after planned preterm delivery: a single-centre retrospective cohort study. Diagnostics (Basel). 2023;13(13):2225. DOI: https://doi.org/10.3390/diagnostics13132225

10. Slidell MB, McAteer J, Miniati D, Sømme S, Wakeman D, Rialon K, et al. Management of gastroschisis: timing of delivery, antibiotic usage, and closure considerations (a systematic review from the American Pediatric Surgical Association Outcomes & Evidence Based Practice Committee). J Pediatr Surg. 2024;59(8):1408-17. DOI: https://doi.org/10.1016/j.jpedsurg.2024.03.044

11. Mesas Burgos C, Irvine W, Vivanti A, Conner P, Machtejeviene E, Peters N, et al. European reference network for rare inherited congenital anomalies (ERNICA) evidence-based guideline on the management of gastroschisis. Orphanet J Rare Dis. 2024;19(1):60. DOI: https://doi.org/10.1186/s13023-024-03062-8

Published

2026-09-04

How to Cite

1.
González Hernández A, Piñon Gamez A, Vinces Obando MC, Muñoz Mendoza AM. Clinical Profile and Therapeutic Approach of Neonates with Congenital Gastrointestinal and Abdominal Wall Anomalies. Rev Cubana Pediatría [Internet]. 2026 Sep. 4 [cited 2026 Sep. 6];98. Available from: https://revpediatria.sld.cu/index.php/ped/article/view/8379

Issue

Section

NEONATOLOGÍA