Perinatal Cytomegalovirus Infection in Very Low Weight Newborns

Authors

Keywords:

perinatal cytomegalovirus, postnatal cytomegalovirus, very low weight neonate

Abstract

Introduction: Preterm and very low weight neonates have higher risk of complications if they acquire cytomegalovirus perinatally.

Objective: To describe the behavior of perinatal cytomegalovirus infection in very low weight neonates.

Design: A descriptive and longitudinal study with 49 neonates was carried out. Congenital cytomegalovirus infection was ruled out from them. These individuals underwent a serial detection of this virus in serum and urine by polymerase chain reaction to determine perinatal infection. Samples of other fluids from their mothers and transfused blood products and perinatal variables were studied; clinical elements and results of complementary examinations in the infected were evaluated.

Results: The incidence of perinatal cytomegalovirus was 18.4% (9/49). 5.2% of the molecular biology tests performed on neonates were positive (11/212). 4.7% of urine samples (5/106) and 5.7% of serum samples (6/106) were positive. thirteen samples were processed from other fluids and one blood cell sample was positive. The incidence of transfusion infection was 7.7% (1/13). 78% of neonates with perinatal infection were asymptomatic at diagnosis, brain ultrasound was abnormal in 22% and in 50% retinopathy of prematurity was detected. Mortality was 11.1% (1/9).

Conclusions: The incidence of perinatal cytomegalovirus infection is high and although the majority did not have alterations related to this disease, one death occurred.

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Author Biographies

Tania Roig Álvarez, Centro de Investigaciones Clínicas.

Especialista de Segundo Grado en Neonatología, Doctora en Ciencias Médicas, Master en Infectología y enfermedades Tropicales, Profesora e Investigadora Titular.

Vivian Kourí Cardellá, Instituto de Medicina Tropical ''Pedro Kourí''.

Especialista de Segundo Grado en Microbiología, Doctora en Ciencias, Master en Virología, Profesora e Investigadora Titular.

Consuelo Correa Sierra, Instituto de Medicina Tropical ''Pedro Kourí''.

Especialista de Primer Grado en Microbiología, Doctora en Ciencias Médicas, Master en Virología

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Published

2024-04-07

How to Cite

1.
Roig Álvarez T, Kourí Cardellá V, Correa Sierra C, Baños Morales Y, Barrios Rentería Y, Arencibia Borroto T, et al. Perinatal Cytomegalovirus Infection in Very Low Weight Newborns. Rev Cubana Pediatría [Internet]. 2024 Apr. 7 [cited 2025 Jun. 14];96. Available from: https://revpediatria.sld.cu/index.php/ped/article/view/4396

Issue

Vol. 96 (2024): Publicación continua

Section

NEONATOLOGÍA

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