Perinatal Risk and Early Antibiotic Use in Preterm Infants under 35 Weeks

Authors

  • Tania Roig Álvarez Hospital Ginecobstétrico Docente “Ramón Gonzalez Coro”
  • Lisandra Medina Cedeño
  • Yamilet Barrios Rentería
  • Aimée Festary Casanova
  • Sandra Aguilar Isla

Keywords:

risk of perinatal infection, early-onset infection, neonatal infection.

Abstract

Introduction: Early-onset neonatal infection is generally acquired from the mother. The most affected group is preterm infants. Management algorithms based on perinatal risk are proposed to reduce the use of antibiotics. Objective: To evaluate the use of antibiotics in the first 72 hours of life, according to perinatal risk, and the epidemiological behavior of early-onset infection in this group. Methods: A descriptive, longitudinal and prospective study was carried out at Ramón González Coro Gynecological and Obstetric Teaching Hospital in Havana, from June to November 2022. Forty-one neonates under 35 weeks of age were included. Results: 53.7% of neonates received antibiotics and their use increased at a younger gestational age. 40.9% were classified as low risk for early-onset infection and 59.1% as high risk. The percentage of neonates with a normal Apgar score, histological chorioamnionitis and definitive diagnosis of early infection was higher in high-risk neonates. The average age of initiation of antibiotic treatment and mortality in the first week of life were higher in low-risk neonates. Infection was not confirmed in 68.2% of neonates who received antimicrobials. The most commonly used combination was ampicillin plus aminoglycoside. Conclusions: Many neonates receive antibacterials without a definitive diagnosis of early infection. The approach to starting and maintaining empirical treatment should be reviewed according to perinatal risk.

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Published

2024-10-01

How to Cite

1.
Roig Álvarez T, Medina Cedeño L, Barrios Rentería Y, Festary Casanova A, Aguilar Isla S. Perinatal Risk and Early Antibiotic Use in Preterm Infants under 35 Weeks. Rev Cubana Pediatría [Internet]. 2024 Oct. 1 [cited 2025 Jun. 14];96. Available from: https://revpediatria.sld.cu/index.php/ped/article/view/5193

Issue

Vol. 96 (2024): Publicación continua

Section

NEONATOLOGÍA

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